Paul O’Gorman Building, University College London,
72 Huntley Street, London, WC1E 6DD
United Kingdom

The Witney Group at UCL's Centre for Advanced Biomedical Imaging. Specialising in the development of advanced cancer imaging tools.

Publications

K.V. Keu*, T.H. Witney*, S. Yaghoubi*, J. Rosenberg, A. Kurien, R. Magnusson, J. Williams, F. Habte, J.R. Wagner, S. Forman, C. Brown, M. Allen-Auerbach, J. Czernin, W. Tang, M.C. Jensen, B. Badie, S.S. Gambhir (2017). Reporter Gene Imaging of Targeted T-Cell Immunotherapy in Recurrent Glioma. Sci Transl Med 9, eeag2196.

 

K. Heinzmann, D.J. Honess, D.Y. Lewis, D-M Smith, C. Cawthorne, H. Keen, S. Heskamp, S. Schelhaas, T.H. Witney, D. Soloviev, K.J. Williams, A.H. Jacobs, E.O. Aboagye, J.R. Griffiths, K.M. Brindle (2016). The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Res 6:63.

 

S. Merchant*, L. Allott*, L.S. Carroll, V. Tittrea, S. Kealey, T.H. Witney, P. Miller, G. Smith and E. O. Aboagye (2016). Synthesis and pre-clinical evaluation of a [18F]fluoromethyl-Tanaproget derivative for imaging of progesterone receptor expression. RSC Adv 6, pp.57569-79.

 

E. Chang, C. Pohling, A. Natarajan, T.H. Witney, J. Kaur, L. Xu, G. Gowrishankar, A. de Souza, S. Murty, S. Schick, L. Chan, N. Wu, P. Khaw, P. Mischel, T. Abbasi, S. Usmani, P. Mallick, S. S. Gambhir (2016). AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models. J Neurooncol 126, pp.253-264.

 

T.H. Witney*, M.L. James*, B. Shen, E. Chang, C. Pohling, N. Arksey, A. Hoehne, F.T. Chin & S.S. Gambhir (2015). PET imaging of tumour glycolyosis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2. Sci Transl Med 7, 310ra169. 

Click on the above link to view the article at Science Translational Medicine. For free access to the full text, please click here.

 

T.H. Witney*, A. Hoehne*, R.E. Reeves, O. Ilovich, M. Namavari, B. Shen, F.T. Chin, J. Rao & S.S Gambhir (2015). A systematic comparison of 18F-C-SNAT to established radiotracer imaging agents for the detection of tumor response to treatment. Clin Cancer Res 21, pp.3896-3905.

 

T.H. Witney, F. Pisaneschi, I.S. Alam, S. Trousil, M. Kaliszczak, F. Twyman, D. Brickute Q. Nguyen, E. Schug, E. Gottlieb & E. O. Aboagye (2014). Preclinical Evaluation of 18F-Fluoro-Pivalic Acid as a Novel Imaging Agent for Tumor Detection. J Nucl Med 55, pp.1506-1512.

 

I.S. Alam, T.H. Witney, G. Tomasi, L. Carroll, F. Twyman, Q.D. Nguyen & E.O. Aboagye (2014).  Radiolabeled RGD tracer kinetics annotates differential αvβ 3 integrin expression linked to cell intrinsic and vessel expression. Mol Imag Biol 16, pp.558-566.

 

S. Merchant, T.H. Witney & E.O. Aboagye (2014). Imaging as a pharmacodynamic and response biomarker in cancer. Clin Transl Imaging 2, pp.13-31.

 

T.H. Witney, R. Fortt & E.O. Aboagye (2014). Preclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by 18F-ICMT-11-Positron Emission Tomography.  PLoS ONE 9(3), e.91694.

 

T.H. Witney, L. Carroll, I.S. Alam, A. Chandrashekran, Q.D. Nguyen, R. Sala, R. Harris, R. J. DeBerardinis, R. Argarwal & E.O. Aboagye (2014). A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography. Cancer Res 47(5), pp.1319-1328.

 

F. Pisaneschi*, T.H. Witney*, L. Iddon* & E.O. Aboagye (2013). Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours. Med Chem Commun 4, pp.1350-1353.

 

L. Carroll, T.H. Witney & E.O. Aboagye (2013). Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging. Med Chem Commun 4, pp.653-656.

 

M.R. Clatworthy, M.I. Kettunen, D-E. Hu, R. Matthews, T.H. Witney, B.W.C. Kennedy, S.E. Bohndiek, F.A. Gallagher, L. Jarvis, K.G.C. Smith, K.M. Brindle (2012). Magnetic resonance imaging with hyperpolarized [1,4-13C2]fumarate allows detection of early renal acute tubular necrosis.  Proc Natl Acad Sci USA 109(33), pp.13374-13379.

 

T.H. Witney, I.A. Alam, D.R. Turton, G. Smith, L. Carroll, D. Brickute, F.J. Twyman, Q-D. Nguyen, G. Tomasi, R. Awais & E.O. Aboagye (2012). Evaluation of Deuterated 18F- and 11C-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography. Clin Cancer Res 18(4), pp.1063-1072.

 

T.H. Witney, M.I. Kettunen & K.M. Brindle (2011).  Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells. J Biol Chem 286, pp.24572-24580.

 

S.E. Bohndiek, M.I. Kettunen, D-E. Hu, T.H. Witney, B.W.C. Kennedy, F.A. Gallagher & K.M. Brindle (2010).  Detecting tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.  Mol Cancer Ther 9(12), pp.3278-3288.

 

T.H. Witney, M.I. Kettunen, D-E. Hu, F.A. Gallagher & K.M. Brindle (2010).  Detecting response to treatment in a model of human breast adenocarcinoma using hyperpolarized [1-13C]pyruvate and [1,4-13C2]fumarate. Brit J Cancer 103, pp.1400-1406.

 

T.H. Witney & K.M Brindle (2010).  Imaging Tumour Cell Metabolism Using Hyperpolarised 13C Magnetic Resonance Spectroscopy. Biochem Soc Trans 38(5), pp.1220-1224.

 

I.A. Alam, A.A. Neves, T.H. Witney, J. Boren & K.M. Brindle (2010). Comparison of the C2A domain of Synaptotagmin-I and Annexin-V as probes for detecting cell death. Bioconjugate Chem 21, pp.884-891.

 

M.I. Kettunen, D-E. Hu, T.H Witney, R. McLaughlin, F.A. Gallagher, S.E Bohndiek & K.M. Brindle (2010).  Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma. Mag Res Med 63(4), pp.872-880.

 

F.A. Gallagher, M.I. Kettunen, D-E. Hu, P.R. Jensen, R. Zandt, M. Karlsson, A. Gisselsson, S.K. Nelson, T.H. Witney, S.E. Bohndiek, G. Hansson, T. Peitersen, M.H. Lerche & K.M. Brindle (2009).  Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate as a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci USA 106(47), pp.19801-6.

 

T.H. Witney, M.I. Kettunen, S.E. Day, D-E. Hu, A.A. Neves, F.A. Gallagher, S.M Fulton, & K.M. Brindle (2009).  A comparison between measurements of radiolabeled fluorodeoxyglucose uptake and hyperpolarized 13C-labeled pyruvate utilization as methods for detecting tumor response to treatment.  Neoplasia 11, pp.574-582.

 

*Joint-first author