Job title: Postdoctoral Research Associate
Department: Centre for Advanced Biomedical Imaging (CABI)
Accountable to: Dr Timothy Witney
Duration: 3 years in the first instance
Purpose of the post: We are seeking a highly motivated and enthusiastic Postdoctoral Research Associate to work at the Centre for Advanced Biomedical Imaging (CABI) on the biological evaluation of novel positron emission tomography (PET) radiotracers for cancer imaging. This is an exciting opportunity to join a vibrant multidisciplinary research group within one of the premier biomedical imaging centres in Europe. The centre has a vast array of small animal imaging modalities, including a state-of-the-art nuclear medicine facility, supported by cutting-edge equipment and core facilities for bioinformatics, flow cytometry and cell sorting, proteomics, genomics, in vivo biology, histopathology, biobanking, as well as GCLP and a clinical research facility. The post holder will plan and conduct a high quality programme of research in the biological evaluation of novel radiotracers for cancer imaging. As part of this programme of work they will determine the time course of uptake, efflux and stability of novel radiotracers developed, both in cells and in living subjects, and evaluate the mechanism of uptake and retention of novel PET radiotracers in tumour cells through gene overexpression, knockdown and subsequent evaluation by flow cytometry and/or immunoblotting.
Position: Cancer Research UK-funded 4 year studentship
The aim of this studentship is to evaluate novel PET radiotracers of therapy resistance in clinically-relevant models of ovarian cancer. This will additionally include investigation of the metabolic pathways that control drug resistance using a stable isotope-based metabolomics approach. The applicant will develop skills in variety of techniques, including radioactive isotope handling, PET imaging, metabolic biochemistry, tumour cell biology, cell culture, flow cytometry and the generation of advanced animal models of human cancer. There is also the potential to gain experience working in the lab of our Industrial collaborator as part of this studentship. Training in all necessary techniques will be provided.
Eligibilty: A minimum of an upper 2nd class Honours Degree in a relevant discipline and some research experience. Applicants need to qualify as UK/EU fee payers and meet UCL general admissions criteria. These four year PhD studentships, funded by Cancer Research UK, include a competitive stipend, consumables funding, a travel allowance, and tuition fees (home/EU rate) paid in full.
Application procedure: To apply*, please e-mail the following pieces of information to CI.Crukcentre@ucl.ac.uk providing the project number(s) and name(s)* in the subject line.
1. An CV highlighting your academic achievement and research experience, as well as stating your nationality and usual country of residence
2. Academic transcripts
3. A short summary (<500 words) detailing how your research interests and academic background matches the project
4. Contact details for two referees
*One application per candidate please. Although you may list more than one project per application, your short summary will need to specify how your background/interests fit each project.
Application Deadline: Applications accepted until 5.00pm Wednesday 6th January 2016.
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